Sargeant Alene, Goswami Tarum, Swank M
Department of Biological Sciences, Ohio Northern University, 525 S. Main Street, Ada, OH 45810, USA.
J Surg Orthop Adv. 2006 Summer;15(2):113-4.
Total hip joint arthroplasty is performed in increasing numbers--about 0.16-0.2% of population per year in industrial countries. In most cases, an implant is a metallic component articulating with a metal, ceramic, or polyethylene liner, used in the hip, knee, and spine. The metal implants release ions in vivo. Toxic concentrations of ions can lead to many adverse physiological effects, including cytotoxicity, genotoxicity, carcinogenicity, and metal sensitivity. Reference levels of ion concentrations in body fluids and tissues determined by many studies are compiled, reviewed, and presented in this article. The concentrations of ions released from different alloys--including cobalt, chromium, nickel, molybdenum titanium, aluminum, and vanadium--are also presented. This article reviews the literature pertaining to clinical data on metal ion concentrations in patients with metal joint prostheses and laboratory data on the physiological effects of the metals.
全髋关节置换术的实施数量在不断增加——在工业化国家，每年约占人口的0.16%至0.2%。在大多数情况下，植入物是与金属、陶瓷或聚乙烯衬垫相连接的金属部件，用于髋关节、膝关节和脊柱。金属植入物在体内会释放离子。离子的毒性浓度会导致许多不良生理效应，包括细胞毒性、遗传毒性、致癌性和金属敏感性。本文汇总、综述并呈现了许多研究所确定的体液和组织中离子浓度的参考水平。还介绍了不同合金（包括钴、铬、镍、钼、钛、铝和钒）释放的离子浓度。本文回顾了有关金属关节假体患者金属离子浓度的临床数据以及金属生理效应的实验室数据的相关文献。
