[发育过程中的小鼠脑神经节苷脂：一种新神经节苷脂的证明]

[Mouse brain gangliosides during development: demonstration of a new ganglioside].

作者信息

Baumann N, Pollet S, Harpin M L

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 Oct 18;283(9):1113-5.

Abstract

The study of gangliosides as a function of age indicates that four of the main components GD1a (G3), GD1b (G2), GT1 (G1) and GQ (G0) are present at birth. They increase with age. On thin-layer chromatography, GD1a seems to be maximum at 18 days and GD1b continues to increase. GM1 increases also from birth to adult age. A new ganglioside has been detected in Mouse brain during its development. Not detected 5 days after birth, it is present at 18 days and in maximal quantity at adult age. This compound does not seem to be correlated to myelination process.

摘要

对神经节苷脂随年龄变化的研究表明，四种主要成分GD1a（G3）、GD1b（G2）、GT1（G1）和GQ（G0）在出生时就已存在。它们随年龄增长而增加。在薄层色谱上，GD1a在18天时似乎达到最大值，而GD1b则持续增加。GM1也从出生到成年期不断增加。在小鼠大脑发育过程中检测到一种新的神经节苷脂。出生后5天未检测到，18天时出现，成年时含量最高。这种化合物似乎与髓鞘形成过程无关。