Packer L, Suzuki Y J
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Mol Aspects Med. 1993;14(3):229-39. doi: 10.1016/0098-2997(93)90009-3.
Nuclear factor kappa B (NF-kappa B) is believed to play an important role in the activation of human immunodeficiency virus (HIV) which causes acquired immunodeficiency syndrome (AIDS). Recent findings suggesting an involvement of reactive oxygen species in signal transduction pathways leading to NF-kappa B activation have encouraged the possible clinical use of antioxidants in blocking HIV activation. We have examined the effects of vitamin E and alpha-lipoate derivatives on NF-kappa B activation, and have observed that each of these antioxidants behave differently. Here we propose mechanisms of antioxidant actions in influencing cell signalling for NF-kappa B activation.
核因子κB（NF-κB）被认为在导致获得性免疫缺陷综合征（AIDS）的人类免疫缺陷病毒（HIV）激活过程中发挥重要作用。最近的研究结果表明，活性氧参与了导致NF-κB激活的信号转导途径，这促使人们考虑在临床上使用抗氧化剂来阻断HIV激活。我们研究了维生素E和α-硫辛酸衍生物对NF-κB激活的影响，发现这些抗氧化剂的作用方式各不相同。在此，我们提出抗氧化剂影响NF-κB激活细胞信号传导的作用机制。
