Bartoli G M, Palozza P, Marra G, Armelao F, Franceschelli P, Luberto C, Sgarlata E, Piccioni E, Anti M
Department of Biology, Tor Vergata University, Rome, Italy.
Mol Aspects Med. 1993;14(3):247-52. doi: 10.1016/0098-2997(93)90011-2.
Subjects at high risk for colon cancer received different doses of fish oil on a 30-day randomized double-blind trial to evaluate the chemopreventive effect of n-3 fatty acids against colorectal cancer. Using rectal mucosal proliferation, assessed with 3H-thymidine autoradiography, fish oil induced in the treated groups but not in the placebo group a change in the proliferative pattern, which resulted similar to that observed in low risk population; in the same groups rectal mucosal n-3 fatty acid content increased, where arachidonic acid level decreased. Moreover, n-3 PUFA treatment induced modifications of Vitamin E status. The results suggest that n-3 PUFA could protect high-risk subjects from colon cancer by a mechanism involving a modulation of Vitamin E.
结肠癌高危受试者在一项为期30天的随机双盲试验中接受了不同剂量的鱼油，以评估n-3脂肪酸对结直肠癌的化学预防作用。通过3H-胸腺嘧啶核苷放射自显影评估直肠黏膜增殖情况，结果显示鱼油在治疗组中诱导了增殖模式的改变，而安慰剂组未出现这种改变，且治疗组的增殖模式与低风险人群中观察到的相似；在相同组中，直肠黏膜n-3脂肪酸含量增加，而花生四烯酸水平降低。此外，n-3多不饱和脂肪酸治疗引起了维生素E状态的改变。结果表明，n-3多不饱和脂肪酸可能通过一种涉及调节维生素E的机制保护高危受试者免受结肠癌的侵害。
