Inada T, Kasuga T, Nojiri I, Furuse T, Hiraoka T
Gan. 1976 Jun;67(3):399-402.
Dependence of the survival curves of Burkitt lymphoma cells, which were featured by their small n or Dq values, on linear energy transfer (LET) obtained for different quality of radiation was revealed markedly in the change of D0 value, together with a small change in n value. Relative biological effectiveness (RBE) compared with Dq, n and D37 values of Burkitt lymphoma cells for high LET radiation was smaller than that of other cell lines. This finding supports the hypothesis that in Burkitt lymphoma cells the recovery capacity from sublethal damage (Dq) is so small even after low LET irradiation that LET does not modify the suppression of recovery. Similar survival curves with n value closely equal to 1 were obtained for four different mammalian cell lines (Burkitt lymphoma p3HR- 1, human melanoma HMV, HeLa-S3, and L5178Y) after 2 MeV neutron irradiation. This fact may suggest that the radiation which has an LET value at which n value of the survival curve is to be 1 will be optimum for therapeutic purpose to the radioresistant tumors.
以小n值或Dq值为特征的伯基特淋巴瘤细胞存活曲线对不同辐射品质下获得的线性能量传递（LET）的依赖性，在D0值变化中明显显现，同时n值有微小变化。与伯基特淋巴瘤细胞在高LET辐射下的Dq、n和D37值相比，相对生物效应（RBE）小于其他细胞系。这一发现支持了以下假设：在伯基特淋巴瘤细胞中，即使在低LET照射后，亚致死损伤（Dq）的恢复能力也非常小，以至于LET不会改变恢复的抑制作用。在2兆电子伏中子照射后，四种不同的哺乳动物细胞系（伯基特淋巴瘤p3HR-1、人黑色素瘤HMV、HeLa-S3和L5178Y）获得了n值接近等于1的相似存活曲线。这一事实可能表明，对于抗辐射肿瘤的治疗目的而言，具有使存活曲线n值为1的LET值的辐射将是最佳的。
