Yagi T, Aizawa S, Tokunaga T, Shigetani Y, Takeda N, Ikawa Y
Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
Nature. 1993;366(6457):742-5. doi: 10.1038/366742a0.
Non-receptor-type tyrosine kinases of the Src family, such as Src, Yes and Fyn, are strongly expressed in the brain and have been suggested to have an important function in the central nervous system. We generated Fyn-deficient mice by inserting the beta-galactosidase gene (lacZ) into the fyn gene. The homozygous Fyn-mutant neonates from homozygous Fyn-deficient parents died because of a suckling problem. Neonates were, however, able to suckle milk normally when the homozygous mother's mammary glands had been activated by suckling of a heterozygous or wild-type pup. In these homozygous pups, the modified glomerular complex of the olfactory bulb, which had been suggested to play a role in perceiving pheromones, was abnormal in shape and reduced in size, and the hippocampal cell-layer was undulated. These results suggest that Fyn may be involved in the initial step of instinctive suckling behaviour in neonates.
Src家族的非受体型酪氨酸激酶，如Src、Yes和Fyn，在大脑中强烈表达，并被认为在中枢神经系统中具有重要功能。我们通过将β-半乳糖苷酶基因（lacZ）插入fyn基因来培育Fyn基因缺陷型小鼠。来自纯合Fyn基因缺陷型亲本的纯合Fyn突变型新生儿因哺乳问题死亡。然而，当纯合母亲的乳腺被杂合或野生型幼崽的哺乳激活时，新生儿能够正常吮吸乳汁。在这些纯合幼崽中，嗅球的改良肾小球复合体形状异常且尺寸减小，而该复合体被认为在感知信息素中起作用，海马细胞层呈波浪状。这些结果表明，Fyn可能参与新生儿本能哺乳行为的初始阶段。
