Wilks J W, Hodgen G D, Ross G T
J Clin Endocrinol Metab. 1976 Dec;43(6):1261-7. doi: 10.1210/jcem-43-6-1261.
Luteal phases of an abbreviated duration or suboptimal progesterone secretion were identified in the rhesus monkey. Characterization of menstrual cycles with short luteal phases (8 days) in 5 monkeys revealed the following deviations from normal: a. a failure of serum FSH to decline progressively from an early follicular phase high to a preovulatory nadir; b. a commonly inadequate, or absent, preovulatory FSH surge; c. subnormal serum LH concentrations during both the follicular and luteal portions of the menstrual cycle; d. ratios of serum FSH:LH which did not progressively decrease during the follicular phase; and e. serum estradiol concentrations below normal values during the luteal portion of the menstrual cycle. One monkey had abnormally low serum concentrations of progesterone, although the luteal phase was 19 days in duration. Serum gonadotropin and estradiol patterns in this latter monkey were identical to those observed in monkeys with short luteal phases. It is concluded that inappropriate ratios of serum FSH:LH during the follicular phase of the menstrual cycle result in impaired corpus leteum function. The data document the usefulness of the nonhuman primate for investigating those luteal phase defects which also occur in the woman.
在恒河猴中发现了黄体期持续时间缩短或孕酮分泌不理想的情况。对5只猴子的短黄体期（8天）月经周期特征进行分析，发现与正常情况有以下偏差：a.血清促卵泡激素（FSH）未能从卵泡早期的高水平逐渐下降至排卵前的最低点；b.排卵前FSH峰通常不足或缺失；c.月经周期的卵泡期和黄体期血清促黄体生成素（LH）浓度均低于正常水平；d.卵泡期血清FSH:LH比值未逐渐下降；e.月经周期黄体期血清雌二醇浓度低于正常值。有一只猴子的孕酮血清浓度异常低，尽管其黄体期持续时间为19天。这只猴子的血清促性腺激素和雌二醇模式与短黄体期猴子所观察到的相同。得出的结论是，月经周期卵泡期血清FSH:LH比例不当会导致黄体功能受损。这些数据证明了非人类灵长类动物在研究女性也会出现的那些黄体期缺陷方面的有用性。
