Winslow R L, Varghese A, Noble D, Adlakha C, Hoythya A
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Proc Biol Sci. 1993 Oct 22;254(1339):55-61. doi: 10.1098/rspb.1993.0126.
A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively parallel CM-5 supercomputer. The model is used to study the effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s-1, pump inhibition in roughly 1000 cells can induce propagating ectopic beats in a 512 x 512 lattice of cells.
一个具有生物物理细节的心脏心房二维网络模型已在思考机器公司的大规模并行CM - 5超级计算机上实现。该模型用于研究钠钾泵空间局部抑制的影响。泵抑制产生的钠过载可在网络内诱发自发的、传播性的异位搏动。在细胞间耦合值产生现实的平面波传导速度为0.6米/秒时，大约1000个细胞中的泵抑制可在512×512个细胞的晶格中诱发传播性异位搏动。
