Motoyoshi F, Kondo N, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Tumour Biol. 1993;14(6):334-7. doi: 10.1159/000217848.
The carbohydrate moieties of glycoproteins in plasma membrane are known to correlate with the induction of cell differentiation in some kinds of cells. We investigated the asparagine-linked sugar chains of neuroblastoma and ganglioneuroma cell membranes. The acidic oligosaccharides were bi-, tri-, and tetraantennary complex-type sugar chains with Man alpha-->(Man alpha)Man beta-->GlcNAc beta-->(+/- Fuc alpha-->)GlcNAc as their cores. A comparative study of the oligosaccharides of these cells showed that the biantennary complex-type sugar chain with bisecting N-acetylglucosamine residues increased and high-molecular-weight oligosaccharides decreased in ganglioneuroma cells. It is suspected that asparagine-linked sugar chains correlate with the differentiation stage of neuroblastoma.
已知质膜中糖蛋白的碳水化合物部分与某些类型细胞的细胞分化诱导相关。我们研究了神经母细胞瘤和神经节神经瘤细胞膜上的天冬酰胺连接糖链。酸性寡糖是具有Manα→(Manα)Manβ→GlcNAcβ→(+/-Fucα→)GlcNAc作为核心的二天线、三天线和四天线复合型糖链。对这些细胞寡糖的比较研究表明，具有平分N-乙酰葡糖胺残基的二天线复合型糖链在神经节神经瘤细胞中增加，而高分子量寡糖减少。据推测，天冬酰胺连接糖链与神经母细胞瘤的分化阶段相关。
