Olthof E, de Vries T W
Afd. Kindergeneeskunde, Academisch Ziekenhuis Groningen.
Tijdschr Kindergeneeskd. 1993 Oct;61(5):175-7.
Oral anticoagulants are frequently prescribed during lactation. Because these drugs could affect the hemostasis of the newborn, we did a literature search to find out whether precautions should be taken. It appeared that acenocoumarol and warfarin are not detectable in human milk. Besides the usual daily supplementation of 25 micrograms vitamin K for every breast-fed infant, precautions are not necessary. Phenprocoumon, ethylbiscoumacetate and phenindione are excreted in human milk and could affect neonatal hemostasis.
哺乳期经常会开具口服抗凝剂。由于这些药物可能会影响新生儿的止血功能，我们进行了文献检索，以确定是否应采取预防措施。结果显示，母乳中检测不到醋硝香豆素和华法林。除了通常每天为每个母乳喂养的婴儿补充25微克维生素K外，无需采取其他预防措施。苯丙香豆素、双香豆乙酯和苯茚二酮可随母乳排出，可能会影响新生儿的止血功能。
