A modeling study of solute reabsorption along rat proximal tubule.

We present a model of steady state solute and water reabsorption along the rat proximal tubule. Major co- and counter-transport systems in the apical and basolateral cell membranes are described using kinetic descriptions based on data from the flows and solute concentrations along the length of the proximal tubule as a function of filtration rate and peritubular solute concentrations. We show that for many aspects of proximal tubule transport physiology this kinetics-based model is an adequate representation of the mammalian proximal tubule.