Wide-Swensson D, Montan S, Arulkumaran S, Ingemarsson I, Ratnam S S
Department of Obstetrics and Gynecology, University Hospital, University of Lund, Sweden.
Am J Obstet Gynecol. 1993 Dec;169(6):1581-5. doi: 10.1016/0002-9378(93)90440-t.
The effects of two antihypertensive drugs, methyldopa and isradipine, on fetal heart rate pattern were analyzed by computerized cardiotocography.
The first part of the study was a prospective, randomized, controlled trial of 19 women with preeclampsia in the third trimester given 2.5 mg of oral slow-release isradipine twice a day or 250 mg of methyldopa three times a day. In a second part of the study 23 women with preeclampsia in the third trimester given 5 mg of oral slow-release isradipine twice a day were compared with 23 matched controls without medication. Main outcome measures were maternal blood pressure and mean baseline fetal heart rate, fetal movements, number of accelerations, periods of high and low baseline variability, and mean baseline heart rate variability.
Compared with the pretreatment value, the mean arterial blood pressure decreased significantly in all drug treatment groups. Fetal heart rate characteristics were not significantly changed during drug treatment or bed rest.
The various features of the fetal heart rate pattern evaluated by computerized methods were not influenced by treatment with methyldopa or isradipine.
通过计算机化心动图分析两种降压药物甲基多巴和伊拉地平对胎儿心率模式的影响。
研究的第一部分是一项前瞻性、随机、对照试验，对19名孕晚期子痫前期妇女进行研究，她们被给予每日两次2.5毫克口服缓释伊拉地平或每日三次250毫克甲基多巴。在研究的第二部分，将23名孕晚期子痫前期妇女每日两次给予5毫克口服缓释伊拉地平与23名未用药的匹配对照进行比较。主要观察指标为孕妇血压、平均基线胎儿心率、胎动、加速次数、高基线和低基线变异性周期以及平均基线心率变异性。
与治疗前值相比，所有药物治疗组的平均动脉血压均显著下降。药物治疗或卧床休息期间胎儿心率特征无显著变化。
通过计算机化方法评估的胎儿心率模式的各种特征不受甲基多巴或伊拉地平治疗的影响。
