Montan S, Anandakumar C, Arulkumaran S, Ingemarsson I, Ratnam S
Department of Obstetrics and Gynecology, National University Hospital National University of Singapore.
J Perinat Med. 1996;24(2):177-84. doi: 10.1515/jpme.1996.24.2.177.
This is a prospective randomised controlled study in 21 women admitted with preeclampsia in the third trimester. The mean arterial blood pressure decreased by 11.1 mmHg (95% confidence interval -14.9 to -7.3 mmHg) in the methyldopa group, and by 9.3 mmHG (95% confidence interval-14.4 to -4.2 mmHG) in the isradipine group. The maternal heart rate decreased by 6.9 beats per min (95% confidence interval -11.6 to -2.2 bpm) during methyldopa treatment, and by 2.5 beats per min (95% confidence interval -9.2 to 4.3) during isradipine treatment. Pulsatility index in maternal and fetal vessels was not affected by either of the two drugs. The birth weight and placental weight and neonatal outcome were similar and uneventful. The hypotensive effect was similar for methyldopa and isradipine. Except reduced maternal heart rate on methyldopa, fetal and uteroplacental hemodynamics were not altered during treatment of preeclampsia with methyldopa or isradipine.
这是一项针对21名孕晚期子痫前期入院女性的前瞻性随机对照研究。甲基多巴组的平均动脉血压下降了11.1 mmHg（95%置信区间为-14.9至-7.3 mmHg），异搏定组下降了9.3 mmHg（95%置信区间为-14.4至-4.2 mmHg）。甲基多巴治疗期间，产妇心率下降了6.9次/分钟（95%置信区间为-11.6至-2.2次/分钟），异搏定治疗期间下降了2.5次/分钟（95%置信区间为-9.2至4.3次/分钟）。两种药物均未影响母胎血管的搏动指数。出生体重、胎盘重量和新生儿结局相似且平稳。甲基多巴和异搏定的降压效果相似。除甲基多巴使产妇心率降低外，在子痫前期治疗中，甲基多巴或异搏定均未改变胎儿及子宫胎盘血流动力学。
