Kaplan M S
Department of Allergy, Kaiser Permanente Medical Center, Oakland, California.
Ann Allergy. 1993 Dec;71(6):529-32.
A case-comparison study compared the allergic and health complications of children who had severe IgE-mediated allergy to cow milk in infancy (study group) with those of other atopic children (control group). Severity of clinical atopy, IgE sensitization to other allergens, and recurrent episodes of anaphylaxis, as well as growth and development were compared in 16 health plan member children aged 2 to 18 years with histories of IgE-mediated anaphylaxis and 16 age- and gender-matched allergy patients. Data were analyzed using the sign test or the signed-rank test of the difference scores of the matched study-control pairs. The results showed the study group differed from the control group throughout childhood by having more specific allergen sensitizations, atopic dermatitis, episodes of sudden severe anaphylaxis, and hospitalizations. Other health complications may exist. Medical care of these children should address these problems.
一项病例对照研究比较了婴儿期对牛奶有严重IgE介导过敏的儿童（研究组）与其他特应性儿童（对照组）的过敏及健康并发症情况。对16名年龄在2至18岁、有IgE介导过敏反应病史的健康计划成员儿童和16名年龄及性别匹配的过敏患者，比较了临床特应性的严重程度、对其他过敏原的IgE致敏情况、过敏反应的复发次数以及生长发育情况。使用配对研究-对照对的差异分数的符号检验或符号秩检验对数据进行分析。结果显示，在整个儿童期，研究组与对照组不同，前者有更多的特异性过敏原致敏、特应性皮炎、突然严重过敏反应发作和住院情况。可能还存在其他健康并发症。对这些儿童的医疗护理应解决这些问题。
