Weber W, Strunk H, Schild H, Steffen W, Stahr P, Erbel R
Department of Radiology, University of Mainz, Medical School, Germany.
Ann Acad Med Singap. 1993 Sep;22(5):696-700.
The aim of the present study was to assess the efficacy and safety of a new ultrasound catheter system in vitro before employing it in humans. Ultrasound energy was applied to 141 normal and atherosclerotic human vessel segments, obtained at autopsy. Macroscopical and histological examination of the treated vessel segments revealed that ultrasound energy is atraumatic to the normal vessel wall. In atherosclerotic vessel segments, there was macroscopically significant reduction in the size of plaques. In 7/10 completely occluded femoral arterial segments, recanalization could be achieved. The resulting lumen approximated the diameter of the wire probe. Therefore, ultrasound energy is an appealing form of energy for recanalization of completely obstructed atherosclerotic vessels and for disintegration of atherosclerotic plaques. Clinically, ultrasonic angioplasty may become an adjunctive modality to balloon angioplasty.
本研究的目的是在将一种新型超声导管系统应用于人体之前，对其进行体外疗效和安全性评估。将超声能量施加于141个在尸检时获取的正常和动脉粥样硬化的人体血管节段。对处理后的血管节段进行宏观和组织学检查发现，超声能量对正常血管壁无创伤。在动脉粥样硬化血管节段，斑块大小在宏观上有显著减小。在10个完全闭塞的股动脉节段中有7个可实现再通。形成的管腔直径接近金属丝探头的直径。因此，超声能量是一种用于完全阻塞的动脉粥样硬化血管再通和动脉粥样硬化斑块分解的有吸引力的能量形式。临床上，超声血管成形术可能会成为球囊血管成形术的辅助手段。
