Strunk H, Weber W, Steffen W, Spielberger M, Düber C, Erbel R, Dietz U, Schäfer M
Klinik mit Poliklinik für Radiologie, Universitätskliniken Mainz.
Rofo. 1992 Jan;156(1):33-6. doi: 10.1055/s-2008-1032832.
Aim of the present study was to examine in vitro the effects of a new ultrasound catheter system on atherosclerotic and normal vessels before employing the system in humans. 141 attempts were made on 32 vascular preparations obtained at autopsy. The vessels were opened longitudinally within 24 hours of death, dilated with gelatine and were then "treated" in a waterbath using varying degrees of pressure, angle of incidence, sound intensity and duration of sound. Macroscopic and histological examinations of the preparation showed no morphological change in normal vessels except evidence of pressure by the catheter. In particular, there were no perforations of the vessel wall. In atherosclerotic segments there was significant reduction in the size of plaques following treatment.
本研究的目的是在将一种新型超声导管系统应用于人体之前，在体外检测其对动脉粥样硬化血管和正常血管的影响。对32份尸检获得的血管标本进行了141次尝试。血管在死亡后24小时内纵向切开，用明胶扩张，然后在水浴中使用不同程度的压力、入射角、声强和声持续时间进行“处理”。对标本的宏观和组织学检查显示，正常血管除有导管施加压力的迹象外，无形态学变化。特别是，血管壁没有穿孔。在动脉粥样硬化节段，治疗后斑块大小显著减小。
