Scherberich J E, Mondorf A W, Jost R
Klin Wochenschr. 1976 Dec 15;54(24):1193-5. doi: 10.1007/BF01469392.
In contrast to findings in healthy people two aminopeptidases with alanine-specifity were found in urine samples of patients after allogenic kidney transplantation. The two aminopeptidases revealed different enzymatic and immunologic properties: one alanine-aminopeptidase (AAP) could be specifically inhibited by a synthetic Thr-Phe-Pro-(tertiary butyl) tripeptide, but was not immunoreactive against an antibody, raised against plasma membranes of human kidney tubule. The tripeptide however was not capable to inhibit the second AAP which exhibited immunoreactive precipitins against the antibody. The appearance of the latter AAP had a close relation to tubular damage during graft rejection episode.
与健康人的检测结果相反，在同种异体肾移植患者的尿液样本中发现了两种具有丙氨酸特异性的氨肽酶。这两种氨肽酶表现出不同的酶学和免疫学特性：一种丙氨酸氨肽酶（AAP）可被合成的苏氨酸-苯丙氨酸-脯氨酸-（叔丁基）三肽特异性抑制，但对针对人肾小管质膜产生的抗体无免疫反应性。然而，该三肽无法抑制第二种AAP，后者对该抗体表现出免疫反应性沉淀素。后一种AAP的出现与移植排斥反应期间的肾小管损伤密切相关。
