Ohshio G, Manabe T, Watanabe Y, Endo K, Kudo H, Suzuki T, Tobe T
Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Am J Gastroenterol. 1990 Oct;85(10):1370-6.
The levels of DU-PAN-2 antigen, carcinoembryonic antigen, and CA19-9 in serum and bile of patients with pancreatic and biliary tract diseases were measured. The sensitivities (true positive) of DU-PAN-2 in serum to pancreatic carcinoma (64%) and to biliary tract carcinoma (62%) were similar to those of CA19-9 in serum (69% and 72%, respectively). Nine of 18 (50%) patients with CA19-9-negative pancreatic carcinoma tested positive for DU-PAN-2. The sensitivities of CEA to pancreatic carcinoma (56%) and to biliary tract carcinoma (52%) were lowest. The measurement of these antigens in bile seemed to be of little diagnostic value in differentiating between malignant and benign diseases. False positives of these three assays occurred frequently in patients with benign pancreatic or biliary tract disease coupled with obstructive jaundice. After percutaneous transhepatic biliary drainage, serum DU-PAN-2 and CA19-9 levels returned to normal ranges in patients with benign diseases, but not in patients with carcinoma of the pancreas or of the biliary tract. Serum CA19-9 and DU-PAN-2 antigens are useful tumor markers for pancreatic and biliary tract carcinomas. Longitudinal assays of these antigens may be useful for the differential diagnosis of patients with obstructive jaundice.
检测了胰腺和胆道疾病患者血清及胆汁中DU-PAN-2抗原、癌胚抗原和CA19-9的水平。血清中DU-PAN-2对胰腺癌（64%）和胆管癌（62%）的敏感性（真阳性）与血清中CA19-9的敏感性（分别为69%和72%）相似。18例CA19-9阴性胰腺癌患者中有9例（50%）DU-PAN-2检测呈阳性。癌胚抗原对胰腺癌（56%）和胆管癌（52%）的敏感性最低。在胆汁中检测这些抗原对于鉴别恶性和良性疾病似乎几乎没有诊断价值。在伴有梗阻性黄疸的良性胰腺或胆道疾病患者中，这三种检测方法经常出现假阳性。经皮经肝胆道引流后，良性疾病患者血清中的DU-PAN-2和CA19-9水平恢复到正常范围，但胰腺癌或胆管癌患者则未恢复。血清CA19-9和DU-PAN-2抗原是胰腺癌和胆管癌有用的肿瘤标志物。对这些抗原进行纵向检测可能有助于对梗阻性黄疸患者进行鉴别诊断。
