[乙醛脱氢酶2（ALDH2）和细胞色素P450 2E1（CYP2E1）基因对日本健康志愿者潮红反应和饮酒模式的影响]

[Contribution of the ALDH2 and CYP2E1 genes to flushing response and drinking patterns in Japanese healthy volunteers].

作者信息

Iwahashi K, Nakamura K, Suwaki H, Matsuo Y, Orino K

机构信息

Department of Neuropsychiatry, Kagawa Medical School, Japan.

出版信息

Arukoru Kenkyuto Yakubutsu Ison. 1993 Oct;28(5):395-9.

PMID:8267522

Abstract

Relationship between genotypes of the loci for ALDH2 and CYP2E1 and the flushing response as well as drinking pattern were investigated among 31 Japanese healthy persons. In 14 persons who showed flushing symptom and whose ALDH2 genotype was heterozygote (ALDH21/ALDH22), 6 persons whose CYP2E1 genotype was mutant homozygote or heterozygote (C2/C2 or C1/C2), reported to drink more frequently and their alcohol consumption was higher than that of C1/C1 carriers. However, 2 subjects possessing C2 allele in 3 persons carrying ALDH2 homozygous genotype showed very low alcohol consumption. It is concluded that a person heterozygous for ALDH2 and either mutant homozygous or heterozygous for CYP2E1 may become able to drink more alcohol, if his drinking pattern grows more frequent.

摘要

在31名日本健康人中，研究了乙醛脱氢酶2（ALDH2）和细胞色素P450 2E1（CYP2E1）基因座的基因型与脸红反应以及饮酒模式之间的关系。在14名出现脸红症状且ALDH2基因型为杂合子（ALDH21/ALDH22）的人中，6名CYP2E1基因型为突变纯合子或杂合子（C2/C2或C1/C2）的人报告饮酒频率更高，且他们的酒精摄入量高于C1/C1携带者。然而，在3名携带ALDH2纯合基因型的人中，有2名携带C2等位基因的受试者酒精摄入量非常低。得出的结论是，如果饮酒模式变得更加频繁，ALDH2杂合子且CYP2E1为突变纯合子或杂合子的人可能会摄入更多酒精。