Iwahashi K, Matsuo Y, Suwaki H, Nakamura K, Ichikawa Y
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Alcohol Clin Exp Res. 1995 Jun;19(3):564-6. doi: 10.1111/j.1530-0277.1995.tb01549.x.
The genotypes of the CYP2E1 and ALDH2 loci of alcoholic (alcohol dependence) and nonalcoholic (healthy) Japanese were investigated to examine the relationship between the polymorphism of CYP2E1 (C1/C2) and ALDH2 (ALDH21/ALDH22), and the susceptibility to alcoholism. There was no significant difference in C2 gene frequency between alcoholics (0.19) and nonalcoholics (controls) (0.20), whereas there was a significant difference in ALDH2 allele frequency, suggesting that, in Japanese, the C2 genotype of CYP2E1 may have nothing to do with the risk of developing alcohol dependence. However, the ALDH2*1 allele may influence drinking behavior and the development of alcohol dependence. Furthermore, racial interethnic differences in the frequency of the mutated allele of the CYP2E1 gene (C2) were found, like the ALDH2 gene. Japanese healthy controls showed a significantly higher frequency of the C2 allele than did Swedish healthy controls (0.05; reported by Persson et al., FEBS Lett. 319:207-211, 1993).
为了研究细胞色素P450 2E1（CYP2E1）基因多态性（C1/C2）和乙醛脱氢酶2（ALDH2）基因多态性（ALDH21/ALDH22）与酒精成瘾易感性之间的关系，对患有酒精性疾病（酒精依赖）和非酒精性疾病（健康）的日本人群的CYP2E1和ALDH2基因座的基因型进行了研究。酒精依赖者（0.19）和非酒精依赖者（对照组，0.20）的C2基因频率没有显著差异，而ALDH2等位基因频率存在显著差异，这表明在日本人中，CYP2E1的C2基因型可能与酒精依赖的风险无关。然而，ALDH2*1等位基因可能会影响饮酒行为和酒精依赖的发展。此外，与ALDH2基因一样，发现CYP2E1基因（C2）突变等位基因频率存在种族间差异。日本健康对照组的C2等位基因频率显著高于瑞典健康对照组（0.05；Persson等人报道，《欧洲生物化学学会联合会快报》319:207 - 211，1993年）。
