Boulot P, Cattaneo A, Taib J, Peray P, Lefort G, Hedon B, Laffargue F, Viala J L
Department of Obstetrics and Gynecology, Hôpital Arnaud-de Villeneuve, Montpellier, France.
Fetal Diagn Ther. 1993 Sep-Oct;8(5):309-16. doi: 10.1159/000263845.
Fetal blood values were evaluated from 541 cordocenteses. Simple regressions were used to find a correlation between blood values and gestational age. We found a linear increase in hemoglobin concentration and hematocrit throughout gestation; a linear decrease of the mean corpuscular volume with the gestation was evidenced as a regular decrease in mean corpuscular hemoglobin. Lastly, the mean corpuscular hemoglobin concentration was constant during the gestation; a linear increase of the platelet count and the nucleated cells was also evidenced. We suggest that each fetal medicine unit should have its own reference ranges. It will permit to accurately diagnose fetal infection, fetal anemia, or any fetal disease where alterations of hematopoiesis have been described.
对541例脐血穿刺获取的胎儿血液值进行了评估。采用简单回归分析来寻找血液值与胎龄之间的相关性。我们发现，整个孕期血红蛋白浓度和血细胞比容呈线性增加；平均红细胞体积随孕周呈线性下降，同时平均红细胞血红蛋白也呈规律性下降。最后，平均红细胞血红蛋白浓度在孕期保持恒定；血小板计数和有核细胞也呈线性增加。我们建议每个胎儿医学单位都应建立自己的参考范围。这将有助于准确诊断胎儿感染、胎儿贫血或任何已描述有造血功能改变的胎儿疾病。
