Schulz E, Heinecke G
MMW Munch Med Wochenschr. 1976 Nov 26;118(48):1559-62.
Eight men with chronic renal disease in the stage of compensated retention were given high doses of the androgen fluoxymesterone (40 mg/m2/day) for erythropoietin stimulation for 4 weeks. Seven of them showed a transient significant average rise in the serum creatinine level of 3.8 to 6.1 mg% which partly regressed only 8 to 12 weeks after stopping the medication. The rise in serum creatinine which appears under fluoxymesterone is attributable to a transient increase in the renal excretory function disturbance and/or a raised catabolism. Warning should be given against the further use of this drug in the treatment of renal anemia.
8名处于代偿性潴留期的慢性肾病男性患者接受了高剂量雄激素氟甲睾酮（40毫克/平方米/天）治疗，以刺激促红细胞生成素，为期4周。其中7人血清肌酐水平出现短暂显著平均升高，从3.8毫克%升至6.1毫克%，仅在停药8至12周后部分有所回落。氟甲睾酮治疗时出现的血清肌酐升高归因于肾排泄功能紊乱的短暂增加和/或分解代谢增强。应警惕在肾性贫血治疗中进一步使用此药。
