López-Rivero L, Quevedo S, Freixinet J, de Castro F R, Liminana M, Salvatierra A, López-Pujol J
Department of Thoracic Surgery, Hospital Ntra. Sra. del Pino, Las Palmas de Gran Canaria, Spain.
Eur J Cardiothorac Surg. 1993;7(10):540-2. doi: 10.1016/1010-7940(93)90053-e.
We assessed omental revascularization of heterotopic tracheal implants in rats, and investigated the influence of factors that can enhance revascularization. The trachea of the donor animal was excised in two parts, and each tracheal allograft was implanted in the omentum of two recipients. The influence of mechanical factors was evaluated by applying traction at both ends of the graft with and without drainage of the tracheal lumen, and the influence of pharmacologic factors by giving cefonicid, hydrocortisone, cefonicid plus hydrocortisone, or cyclosporine and azathioprine during the postoperative period. Revascularization of the graft from the omentum with preservation of the tracheal structure was established. Graft viability showed significant differences between the tracheal implants to which no traction had been applied and those with traction at both ends. Tracheal allografts from animals receiving immunosuppressants were completely viable and no significant differences were found between the controls and animals in this group.
我们评估了大鼠异位气管移植物的网膜血管再生情况，并研究了可增强血管再生的因素的影响。将供体动物的气管切成两部分，每块气管同种异体移植物植入两只受体的网膜中。通过在移植物两端施加牵引（有无气管腔引流）来评估机械因素的影响，并通过在术后给予头孢尼西、氢化可的松、头孢尼西加氢化可的松或环孢素和硫唑嘌呤来评估药理因素的影响。建立了来自网膜的移植物的血管再生且气管结构得以保留。未施加牵引的气管移植物与两端施加牵引的气管移植物之间的移植物活力存在显著差异。接受免疫抑制剂的动物的气管同种异体移植物完全存活，该组动物与对照组之间未发现显著差异。
