Cargill J M, Saunders J H, Peden N, Wormsley K G
Lancet. 1978 Nov 25;2(8100):1113-5. doi: 10.1016/s0140-6736(78)92273-0.
In an open trial, 96 patients with endoscopically proven peptic ulcers were randomly allocated to treatment with cimetidine (1 g/day) for periods of 3, 6, 9, or 12 months. After their courses of treatment, the patients were followed up for at least 6 months. In 92% the ulcers had healed after treatment for 1 month, and in a further 5% the ulcers healed during the next 2 months. Ulcers recurred during treatment in 24% of patients and within 6 months of withdrawal of treatment in a further 43%. In nearly a third of patients the recurrences were asymptomatic and were discovered only through routine endoscopic studies. Continuous treatment with full doses of cimetidine for a year seems to prevent relapse of the majority of ulcers which have healed during treatment; but it does not cure the ulcer disease, since relapse generally occurs quite rapidly when treatment is discontinued.
在一项开放性试验中，96例经内镜证实患有消化性溃疡的患者被随机分配接受西咪替丁治疗（1克/天），疗程分别为3、6、9或12个月。治疗结束后，对患者进行了至少6个月的随访。92%的患者在治疗1个月后溃疡愈合，另有5%的患者在接下来的2个月内溃疡愈合。24%的患者在治疗期间溃疡复发，停药后6个月内另有43%的患者溃疡复发。近三分之一的患者复发时无症状，仅通过常规内镜检查才被发现。用全剂量西咪替丁持续治疗一年似乎可预防大多数在治疗期间已愈合的溃疡复发；但它并不能治愈溃疡病，因为停药后复发通常很快就会发生。
