Watanabe H, Kuwabara T, Ohkubo M, Sakai K, Tsuji S, Yuasa T
Department of Neurology, Brain Research Institute, Niigata University, Japan.
No To Shinkei. 1993 Oct;45(10):941-4.
The effects of photic stimulation on the visual cortex of human brain were studied by means of gradient-echo magnetic resonance imaging (MRI). Fast low-angle shot (FLASH) MRI was used to monitor changes in brain oxygenation in the human visual cortex during photic stimulation (PS). Whole-body 1.5 T clinical MR system was used. Elevation of image intensity up to 2% was observed in primary and associative visual cortex, corresponding to an increase of blood oxygenation in regions of increased neural activity. After the PS was switched off, the MR signal fell below the pre-PS baseline level, which may be understood as an displacement of the oxygen-hemoglobin dissociation curve (the Bohre effect).
采用梯度回波磁共振成像（MRI）研究了光刺激对人脑视觉皮层的影响。使用快速低角度激发（FLASH）MRI监测光刺激（PS）期间人类视觉皮层的脑氧合变化。采用全身1.5T临床MR系统。在初级和联合视觉皮层中观察到图像强度升高高达2%，这对应于神经活动增加区域的血液氧合增加。在光刺激关闭后，MR信号降至光刺激前基线水平以下，这可能被理解为氧合血红蛋白解离曲线的位移（玻尔效应）。
