Lankes W T, Schwartz-Albiez R, Furthmayr H
Department of Pathology, Stanford University School of Medicine, CA 94305-5324.
Biochim Biophys Acta. 1993 Dec 14;1216(3):479-82. doi: 10.1016/0167-4781(93)90018-9.
The full length cDNA of porcine moesin and radixin have been cloned and sequenced. Comparison of the closely related sequences of human, murine and porcine moesin, ezrin and radixin with a protein from Echinococcus multilocularis, an evolutionarily quite distant human parasite, reveals several highly invariant domains in the aminoterminal and carboxyterminal regions. Most of these conserved domains are clustered around tyrosine residues that are putative phosphorylation sites for tyrosine phosphokinases.
猪肌动蛋白结合蛋白和根蛋白的全长cDNA已被克隆和测序。将人类、小鼠和猪的肌动蛋白结合蛋白、埃兹蛋白和根蛋白的密切相关序列与多房棘球绦虫（一种在进化上与人类相距甚远的寄生虫）的一种蛋白质进行比较，发现在氨基末端和羧基末端区域有几个高度保守的结构域。这些保守结构域大多聚集在酪氨酸残基周围，而酪氨酸残基是酪氨酸磷酸激酶的假定磷酸化位点。
