人胚胎前清蛋白作为肿瘤和成纤维细胞的标志物。
Human embryonic prealbumin as a marker for tumours and fibroblasts.
作者信息
Tatarinov Y S, Kalashnikov V V, Vasiliev M Y, Voloshuk S G, Kraevsky N A, Vorsanova S G
出版信息
Lancet. 1978 Nov 25;2(8100):1122-3. doi: 10.1016/s0140-6736(78)92276-6.
PMID:82683
Abstract
Embryonic prealbumin (E.P.A.) was demonstrated by agar immunodiffusion in 122 out of 505 homogenates of various tumours and in 7 out of 20 serum samples from patients with connective-tissue tumours. Analogous antigen was found in human embryonic and adult cultured fibroblasts. This newly identified antigen is probably actively secreted by fibroblasts into the circulation of patients with tumours.
摘要
通过琼脂免疫扩散法在505份各种肿瘤匀浆中的122份以及20份结缔组织肿瘤患者血清样本中的7份中检测到胚胎前白蛋白（E.P.A.）。在人胚胎和成体培养的成纤维细胞中发现了类似抗原。这种新发现的抗原可能由成纤维细胞主动分泌到肿瘤患者的循环系统中。
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