HLA-D/DR配型在肾移植中的意义。
Significance of HLA-D/DR matching in renal transplantation.
作者信息
Albrechtsen D, Flatmark A, Jervell J, Halvorsen S, Solheim B G, Thorsby E
出版信息
Lancet. 1978 Nov 25;2(8100):1126-7. doi: 10.1016/s0140-6736(78)92278-x.
A low mixed-lymphocyte-culture response, indicating matching for HLA-D, was associated with a relatively good chance of graft survival in 62 recipients of renal transplants from living relatives mismatched for one or two HLA A and/or B antigens. In 96 cadaveric transplants prospectively typed for HLA-DR antigens, compatibility for these antigens improved the prognosis, irrespective of matching for HLA A and B antigens. In cadaveric transplants, a positive B-cell cross-match test before transplantation tended to predict inferior graft survival.
低混合淋巴细胞培养反应表明HLA - D匹配，这与62例接受来自亲属的肾移植患者（供受者在一个或两个HLA A和/或B抗原上不匹配）相对较好的移植存活几率相关。在96例对HLA - DR抗原进行前瞻性分型的尸体肾移植中，这些抗原的相容性改善了预后，而与HLA A和B抗原的匹配无关。在尸体肾移植中，移植前B细胞交叉配型试验呈阳性往往预示移植存活情况较差。
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