Thorsby E, Moen T, Solheim B G, Albrechtsen D, Jakobsen A, Jervell J, Halvorsen S, Flatmark A
Tissue Antigens. 1981 Jan;17(1):83-90. doi: 10.1111/j.1399-0039.1981.tb00670.x.
The outcome of 461 prospectively HLA-A, -B and -C typed and 193 prospectively HLA-DR typed cadaveric kidney transplants in one center was followed. We found a significant beneficial effect on graft survival both of HLA-A and -B as well as of HLA-DR matching between donor and recipient, while no effects of HLA-C compatibility could be detected. The effect of HLA-DR matching was clearly more pronounced than that of HLA-A and -B matching, and a possible influence of matching for HLA-A and -B could only be seen in the HLA-DR mismatched combinations. Pretransplant blood transfusions were associated with an increased graft survival only in patients receiving HLA-DR mismatched transplants. We conclude that major emphasis should be laid on obtaining HLA-DR compatibility in clinical renal transplantation.
对一个中心461例前瞻性进行HLA - A、- B和- C分型以及193例前瞻性进行HLA - DR分型的尸体肾移植结果进行了随访。我们发现供体与受体之间的HLA - A和- B以及HLA - DR配型对移植肾存活均有显著的有益影响，而未检测到HLA - C相容性的影响。HLA - DR配型的影响明显比HLA - A和- B配型更显著，并且只有在HLA - DR错配组合中才能看到HLA - A和- B配型的可能影响。移植前输血仅在接受HLA - DR错配移植的患者中与移植肾存活增加相关。我们得出结论，临床肾移植应主要强调获得HLA - DR相容性。
