Fine J M, Blatrix C, Marneux M, Valentin L, Lambin P
Nouv Presse Med. 1976 Nov 27;5(40):2694-6.
The relatives of a 82 years old female patients with a Waldenstrom Macroglobulinemia were submitted to clinical and hematological investigations. A diclonal gammapathy (IgG kappa and IgG lambda) was found in the sister's serum and was related to a myeloma. A noticiable Bence Jones Proteinuria (light chain of lambda type) was equally found in serum and urines of the propositus brother but without any clinical or hematological evidence of myeloma. The examination of two other sisters of these patients does not reveal any immunological of hematological disorder. This new observation underlines the interest of a systematical investigation in the siblings of the patients with monoclonal gammapathies.
对一名患有华氏巨球蛋白血症的82岁女性患者的亲属进行了临床和血液学检查。在其姐妹的血清中发现了双克隆丙种球蛋白病（IgG κ和IgG λ），且与骨髓瘤有关。在该患者的兄弟的血清和尿液中同样发现了明显的本周蛋白尿（λ型轻链），但没有骨髓瘤的任何临床或血液学证据。对这些患者的另外两名姐妹的检查未发现任何血液学免疫紊乱。这一新发现强调了对单克隆丙种球蛋白病患者的兄弟姐妹进行系统检查的重要性。
