Mimran A, Ribstein J
Department of Medicine Centre Hospitalier Universitaire Montpellier, France.
Clin Exp Hypertens. 1993 Nov;15(6):1061-7. doi: 10.3109/10641969309037093.
The prevalence and significance of microalbuminuria is not well elucidated in patients with essential hypertension. In newly detected hypertension, its prevalence ranges between 23 and 37% and albuminuria is usually well correlated with the level of arterial pressure. Interestingly, albuminuria is enhanced in overweight hypertensive patients. Antihypertensive treatment has variable influence on albuminuria, and converting enzyme inhibitors, in contrast to other agents, tend to partially correct this abnormality. Whether microalbuminuria represents a predictor of the future development of nephrosclerosis and ultimately renal failure, or a predictor of cardiovascular morbidity deserves to be investigated.
原发性高血压患者中微量白蛋白尿的患病率及意义尚未得到充分阐明。在新发现的高血压患者中,其患病率在23%至37%之间,且蛋白尿通常与动脉压水平密切相关。有趣的是,超重高血压患者的蛋白尿会加重。降压治疗对蛋白尿有不同影响,与其他药物相比,转换酶抑制剂往往能部分纠正这种异常。微量白蛋白尿是肾硬化及最终肾衰竭未来发展的预测指标,还是心血管疾病发病率的预测指标,值得研究。