Mimran A
Department of Medicine, Centre Hospitalier Universitaire, Montpellier, France.
Clin Exp Hypertens. 1997 Jul-Aug;19(5-6):753-67. doi: 10.3109/10641969709083184.
The prevalence of microalbuminuria in patients with essential hypertension ranges between 10 and 25%. The level of albuminuria is highly correlated with arterial pressure and more closely ambulatory arterial pressure. The interaction between albuminuria and arterial pressure is enhanced by overweight and smoking. The renal mechanisms of microalbuminuria are not well elucidated; however, an increase in filtration fraction suggestive of intraglomerular hypertension was observed in patients with hyperfiltration. The significance of microalbuminuria as a marker of cardiovascular risk or hypertensive renal damage needs to be confirmed through long-term follow-up studies. Antihypertensive treatment has variable influence on albuminuria; and angiotensin-converting enzyme inhibitors and to a lesser extent other agents, tend to partially correct this abnormality.
原发性高血压患者微量白蛋白尿的患病率在10%至25%之间。蛋白尿水平与动脉压高度相关，与动态动脉压的相关性更强。超重和吸烟会增强蛋白尿与动脉压之间的相互作用。微量白蛋白尿的肾脏机制尚未完全阐明；然而，在超滤患者中观察到滤过分数增加，提示肾小球内高压。微量白蛋白尿作为心血管风险或高血压肾损害标志物的意义需要通过长期随访研究来证实。降压治疗对蛋白尿有不同的影响；血管紧张素转换酶抑制剂以及程度较轻的其他药物往往会部分纠正这种异常。
