转化生长因子β（TGF-β）在系统性自身免疫中的作用。
Role of transforming growth factor beta (TGF beta) in systemic autoimmunity.
作者信息
Del Giudice G, Crow M K
机构信息
Hospital for Special Surgery, New York Hospital-Cornell Medical Center, New York.
出版信息
Lupus. 1993 Aug;2(4):213-20. doi: 10.1177/096120339300200402.
PMID:8268968
Abstract
Transforming growth factor (TGF beta) is a multifunctional cytokine with proinflammatory as well as immunosuppressive activities. A regulatory role for TGF beta has been suggested in investigations of several experimental and spontaneous models of pathological autoreactivity. It is suggested that many of the functional effects of TGF beta parallel the major immune system abnormalities seen in SLE.
摘要
转化生长因子（TGF-β）是一种具有促炎和免疫抑制活性的多功能细胞因子。在对几种病理性自身反应性的实验和自发模型的研究中，已表明TGF-β具有调节作用。有人提出，TGF-β的许多功能效应与系统性红斑狼疮（SLE）中所见的主要免疫系统异常情况相似。
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