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The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications.

作者信息

Horwitz D A, Jacob C O

机构信息

Department of Medicine, University of Southern California, School of Medicine, Los Angeles.

出版信息

Springer Semin Immunopathol. 1994;16(2-3):181-200. doi: 10.1007/BF00197516.

DOI:10.1007/BF00197516
PMID:7716704
Abstract
摘要

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Safety and efficacy of hCDR1 (Edratide) in patients with active systemic lupus erythematosus: results of phase II study.hCDR1（Edratide）治疗活动性系统性红斑狼疮患者的安全性和疗效：II 期研究结果。
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本文引用的文献

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Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.转化生长因子-β1、白细胞介素-4、去甲肾上腺素和糖皮质激素对干扰素-γ诱导的分离小胶质细胞上主要组织相容性复合体II类分子和Fc受体表达的调节作用。
Immunology. 1993 May;79(1):125-30.
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Systemic immunological effects of cytokine genes injected into skeletal muscle.注射到骨骼肌中的细胞因子基因的全身免疫效应。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4523-7. doi: 10.1073/pnas.90.10.4523.
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Modified immunological status of anti-IL-10 treated mice.
耐受肽 hCDR1 下调鼠和人系统性红斑狼疮中干扰素-α的表达。
PLoS One. 2013;8(3):e60394. doi: 10.1371/journal.pone.0060394. Epub 2013 Mar 28.
4
Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches.系统性红斑狼疮中的动脉粥样硬化加速：促炎细胞因子的作用及治疗方法
J Biomed Biotechnol. 2010;2010. doi: 10.1155/2010/607084. Epub 2010 Sep 26.
5
A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide.诱导性实验性系统性红斑狼疮（SLE）在猪中的新模型及其用耐受肽治疗的改善。
J Clin Immunol. 2010 Jan;30(1):34-44. doi: 10.1007/s10875-009-9326-4. Epub 2009 Sep 16.
6
High alpha-defensin levels in patients with systemic lupus erythematosus.系统性红斑狼疮患者体内α-防御素水平较高。
Immunology. 2009 May;127(1):116-22. doi: 10.1111/j.1365-2567.2008.02997.x.
7
Tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and their soluble receptors (sTNF-alpha-Rp55 and slL-6R) serum levels in systemic lupus erythematodes.系统性红斑狼疮患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）及其可溶性受体（sTNF-α-Rp55 和 slL-6R）血清水平。
Mediators Inflamm. 1996;5(6):435-41. doi: 10.1155/S0962935196000609.
8
Intrarenal cytokine gene expression in lupus nephritis.狼疮性肾炎中的肾内细胞因子基因表达
Ann Rheum Dis. 2007 Jul;66(7):886-92. doi: 10.1136/ard.2006.063123. Epub 2007 Feb 26.
9
Correlation between levels of TNF-alpha and IL-6 and hematological involvement in SLE Egyptian patients with lupus nephritis.埃及狼疮性肾炎系统性红斑狼疮患者中肿瘤坏死因子-α和白细胞介素-6水平与血液学受累情况的相关性
Int Urol Nephrol. 2006;38(3-4):731-7. doi: 10.1007/s11255-006-0047-9. Epub 2007 Jan 27.
10
A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation.一种基于人单克隆自身抗体互补决定区1的肽可改善自发性和诱发性狼疮表现，并与细胞因子免疫调节相关。
J Clin Immunol. 2004 Nov;24(6):579-90. doi: 10.1007/s10875-004-6245-2.
抗白细胞介素-10治疗小鼠的免疫状态改变
Cell Immunol. 1993 May;148(2):371-84. doi: 10.1006/cimm.1993.1119.
4
Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases.系统性红斑狼疮、类风湿关节炎及其他风湿性疾病中的细胞因子谱。
J Clin Immunol. 1993 Jan;13(1):58-67. doi: 10.1007/BF00920636.
5
The soluble interleukin-6 receptor is generated by shedding.可溶性白细胞介素-6受体通过脱落产生。
Eur J Immunol. 1993 Feb;23(2):473-80. doi: 10.1002/eji.1830230226.
6
Differential shedding of the two subunits of the interleukin-6 receptor.白细胞介素-6受体两个亚基的差异性脱落
FEBS Lett. 1993 Oct 11;332(1-2):174-8. doi: 10.1016/0014-5793(93)80507-q.
7
Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.系统性红斑狼疮患者血清可溶性肿瘤坏死因子受体水平与疾病活动度的相关性
Arthritis Rheum. 1993 Aug;36(8):1111-20. doi: 10.1002/art.1780360812.
8
The hematopoietin receptor superfamily.造血因子受体超家族。
Cytokine. 1993 Mar;5(2):95-106. doi: 10.1016/1043-4666(93)90047-9.
9
Regulation of natural killer cell activity by transforming growth factor-beta and prostaglandin E2.转化生长因子-β和前列腺素E2对自然杀伤细胞活性的调节
Scand J Immunol. 1993 Jan;37(1):71-6. doi: 10.1111/j.1365-3083.1993.tb01667.x.
10
T cell-antigen-presenting cell interactions in human systemic lupus erythematosus. Evidence for heterogeneous expression of multiple defects.人类系统性红斑狼疮中T细胞与抗原呈递细胞的相互作用。多种缺陷异质性表达的证据。
J Immunol. 1993 Oct 1;151(7):3914-22.