Peeke S C, Jones R T, Stone G C
Psychopharmacology (Berl). 1976 Jul 28;48(2):159-63. doi: 10.1007/BF00423255.
The effect of smoked marijuana on performance of complex reaction time (RT) tasks was studied in two groups receiving different amounts of practice. Group M-P had no undrugged practice on the task before performing during marijuana intoxication for four consecutive daily sessions. On the fifth test day they performed while non-intoxicated. Group P-M performed the task on four consecutive test days while non-intoxicated, then smoked marijuana on session 5. Significant RT slowing was found on session 1 for group M-P (performing during marijuana intoxication without prior practice). Performance of this group improved rapidly and by the end of session 2 was not different from undrugged performance. Group P-M (receiving four sessions of undrugged practice before marijuana intoxication) showed no RT slowing while intoxicated. Reaction time performance may involve two phases: an early, attention-demanding phase which is sensitive to drug effects and a later, "automatic", phase which results from practice and is more resistant to drug effects. Pulse rate, salivary flow and subjective responses were recorded before and after smoking. These physiological and subjective measures showed only slight reduction in the acute effects of the drug over the four days of repeated usage.
在两组接受不同练习量的人群中，研究了吸食大麻对复杂反应时间（RT）任务表现的影响。M-P组在连续四天吸食大麻致毒期间执行任务前，未进行无毒品状态下的练习。在第五个测试日，他们在未中毒的状态下执行任务。P-M组在连续四个测试日未中毒状态下执行任务，然后在第五次测试时吸食大麻。发现M-P组在第一天（在吸食大麻致毒期间执行任务且无先前练习）反应时间显著减慢。该组表现迅速改善，到第二天结束时与未吸毒时的表现无异。P-M组（在吸食大麻致毒前接受了四次无毒品状态下的练习）在中毒时未出现反应时间减慢。反应时间表现可能涉及两个阶段：早期的、需要注意力的阶段，对药物作用敏感；以及后期的“自动”阶段，这是练习的结果，对药物作用更具抵抗力。在吸食前后记录脉搏率、唾液流量和主观反应。这些生理和主观指标显示，在重复使用药物的四天里，药物的急性效应仅有轻微降低。
