Slepnev V I, De Camilli P
Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA.
Nat Rev Neurosci. 2000 Dec;1(3):161-72. doi: 10.1038/35044540.
Clathrin-mediated endocytosis is a special form of vesicle budding important for the internalization of receptors and extracellular ligands, for the recycling of plasma membrane components, and for the retrieval of surface proteins destined for degradation. In nerve terminals, clathrin-mediated endocytosis is crucial for synaptic vesicle recycling. Recent structural studies have provided molecular details of coat assembly. In addition, biochemical and genetic studies have identified numerous accessory proteins that assist the clathrin coat in its function at synapses and in other systems. This review summarizes these advances with a special focus on accessory factors and highlights new aspects of clathrin-mediated endocytosis revealed by the study of these factors.
网格蛋白介导的内吞作用是一种特殊的囊泡出芽形式，对于受体和细胞外配体的内化、质膜成分的循环利用以及 destined for degradation（此处原文有误，推测是“注定要降解的表面蛋白的回收”）而言至关重要。在神经末梢中，网格蛋白介导的内吞作用对于突触囊泡的循环利用至关重要。最近的结构研究提供了衣被组装的分子细节。此外，生化和遗传学研究已经鉴定出许多辅助蛋白，这些蛋白在突触和其他系统中协助网格蛋白衣被发挥功能。本综述总结了这些进展，特别关注辅助因子，并强调了通过对这些因子的研究揭示的网格蛋白介导的内吞作用的新方面。
