Ueno M, Amemiya M, Someno T, Masuda T, Iinuma H, Naganawa H, Hamada M, Ishizuka M, Takeuchi T
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
J Antibiot (Tokyo). 1993 Nov;46(11):1658-65. doi: 10.7164/antibiotics.46.1658.
In our search for inhibitors of cell adhesion to components of extracellular matrix (ECM), fibronectin, laminin and collagen type IV, we succeeded in finding a novel cyclic hexadepsipeptide antibiotic, named IC101, which was isolated from cultured mycelium of Streptomyces albulus MJ202-72F3. It was purified by centrifugal partition chromatography, preparative reverse phase HPLC and Sephadex LH-20 and was obtained as a white powder. IC101 strongly inhibited cell adhesion to ECM components, suppressed immune responses in vitro and in vivo, and exhibited antimicrobial activity on Gram-positive bacteria.
