聚酮霉素，一种来自链霉菌属MK277-AF1的新型抗生素。I. 分类学、生产、分离、理化性质及生物活性。
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
作者信息
Momose I, Chen W, Kinoshita N, Iinuma H, Hamada M, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Jan;51(1):21-5. doi: 10.7164/antibiotics.51.21.
A new antibiotic designated polyketomycin was isolated from the culture broth of Streptomyces sp. MK277-AF1. It was purified by ethyl acetate extraction, Sephadex LH-20 column chromatography and centrifugal partition chromatography (CPC). It inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Its MICs were less than 0.2 microgram/ml. Polyketomycin exhibited cytotoxic activity against nine tumor cell lines at concentrations of 0.9-5.2 micrograms/ml.
从链霉菌属菌株MK277-AF1的培养液中分离出一种名为聚酮霉素的新型抗生素。通过乙酸乙酯萃取、葡聚糖凝胶LH-20柱色谱法和离心分配色谱法（CPC）对其进行纯化。它能抑制包括耐甲氧西林金黄色葡萄球菌（MRSA）在内的革兰氏阳性菌的生长。其最低抑菌浓度小于0.2微克/毫升。聚酮霉素在浓度为0.9 - 5.2微克/毫升时对九种肿瘤细胞系表现出细胞毒性活性。
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