Kawatsu M, Yamashita T, Osono M, Ishizuka M, Takeuchi T
Institute for Chemotherapy, M.C.R.F., Shizuoka, Japan.
J Antibiot (Tokyo). 1993 Nov;46(11):1687-91. doi: 10.7164/antibiotics.46.1687.
Conagenin (CNG), a low molecular immunomodulator, enhanced incorporation of [3H]thymidine into T cells activated by concanavalin A but did not to non-activated T cells. The culture supernatants of activated T cells treated with CNG enhanced incorporation of [3H]thymidine into cytokine dependent cell lines, CTLL-2 and IC-2 cells. This indicates that CNG exclusively acts on activated T cells and stimulates them to promote DNA synthesis and to produce lymphokines, which may include T cell growth factors and hematopoietic growth factors. These activities were also observed with T cells taken from mice given CNG.
伴刀豆球蛋白A（Conagenin，CNG）是一种低分子免疫调节剂，它能增强[3H]胸腺嘧啶核苷掺入到由刀豆球蛋白A激活的T细胞中，但对未激活的T细胞无此作用。用CNG处理的激活T细胞培养上清液能增强[3H]胸腺嘧啶核苷掺入到细胞因子依赖性细胞系CTLL-2和IC-2细胞中。这表明CNG仅作用于激活的T细胞，并刺激它们促进DNA合成和产生淋巴因子，其中可能包括T细胞生长因子和造血生长因子。从小鼠体内获取的给予CNG后的T细胞也观察到了这些活性。
