Heidl G, Langhans P, Mellin W, Bünte H, Grundmann E
Institut für Pathologie, Siegen, Germany.
J Cancer Res Clin Oncol. 1993;120(1-2):95-9. doi: 10.1007/BF01200731.
Since the carcinomas of the cardia and the adenocarcinomas of the esophagus show many similarities in their histological and morphological descriptions, a detailed comparative study was attempted on the basis of 66 esophageal carcinomas in adenoid differentiation, 359 carcinomas of the cardia, 1288 gastric carcinomas in infracardial localisation, and 492 squamous carcinomas of the esophagus. The evaluation yielded no significant differences between the adenocarcinomas of the esophagus and the cardia neither in age and sex distribution nor with regard to the classifications of Borrmann, WHO, Ming, and Laurén, but a significant discrimination was possible between esophageal and cardial adenocarcinoma together, on the one hand, and infracardial gastric carcinoma on the other. Furthermore, esophageal adenocarcinomas were localized preferentially in the lower third, unlike squamous carcinomas of the same organ. These results suggest that esophageal adenocarcinoma and carcinoma of the cardia must be considered as one separate entity, probably originating from a common stem cell. They further suggest that the cardia belongs to the esophagus rather than to the stomach.
由于贲门癌和食管腺癌在组织学和形态学描述上有许多相似之处，因此对66例腺样分化的食管癌、359例贲门癌、1288例贲门以下定位的胃癌以及492例食管鳞癌进行了详细的比较研究。评估结果显示，食管腺癌和贲门癌在年龄和性别分布以及Borrmann、WHO、Ming和Laurén分类方面均无显著差异，但一方面食管和贲门腺癌与另一方面贲门以下胃癌之间存在显著差异。此外，与同一器官的鳞癌不同，食管腺癌优先定位于下三分之一处。这些结果表明，食管腺癌和贲门癌必须被视为一个单独的实体，可能起源于共同的干细胞。它们还表明，贲门属于食管而非胃。
