Mizukami Y, Yokoyama T
Department of Hospital Pharmacy, Kyoto Phrmaceutical University.
Kansenshogaku Zasshi. 1993 Nov;67(11):1052-6. doi: 10.11150/kansenshogakuzasshi1970.67.1052.
To evaluate the bactericidal activity of povidone-iodine (PVI), synthetic mediums without the protein components were prepared. The stability of the available iodine in the synthetic mediums was compared with that in heart infusion broth (HIB; natural broth). The available iodine was remarkably decreased soon after addition of PVI in the HIB, but it was stable for 24 hr in the synthetic mediums. The growth of Escherichia coli and Salmonella enteritidis were found to be normal in the synthetic mediums. Minimal inhibitory concentrations (MICs) of PVI in the synthetic mediums were about one thousandth of that in HIB, and the phenol coefficients (PCs) of PVI in the synthetic mediums were about 30 times lower than that in the HIB.
为评估聚维酮碘（PVI）的杀菌活性，制备了不含蛋白质成分的合成培养基。将合成培养基中有效碘的稳定性与心浸液肉汤（HIB；天然肉汤）中的稳定性进行比较。在HIB中加入PVI后，有效碘很快显著降低，但在合成培养基中它在24小时内保持稳定。发现大肠杆菌和肠炎沙门氏菌在合成培养基中生长正常。合成培养基中PVI的最低抑菌浓度（MIC）约为HIB中的千分之一，合成培养基中PVI的酚系数（PC）比HIB中的低约30倍。
