Vreeling F W, Verhey F R, Houx P J, Jolles J
University of Limburg, Maastricht, The Netherlands.
J Neurol Neurosurg Psychiatry. 1993 Dec;56(12):1323-6. doi: 10.1136/jnnp.56.12.1323.
A standardised protocol for the examination of 15 primitive reflexes in which the amplitude and the persistence were scored separately, was applied to 25 patients with Parkinson's disease and an equal number of healthy matched control subjects. Most reflexes were found considerably more often in the patients than in the control subjects, especially the snout, the glabellar tap, and its variant, the nasopalpebral reflex. Only the mouth open finger spread reflex was present more often in the control subjects. For all reflexes except this last, the scores for amplitude and persistence of the reflexes for the control group never exceeded the scores for the patient group. Reflexes persisted more often in the patients than in the control subjects. Parkinsonism alone can explain a large number of primitive reflexes, irrespective of the severity or duration of the disease. In contrast, the number of reflexes was related more closely to cognitive scales. It is concluded that such reflexes may be helpful in diagnosing Parkinson's disease. In addition, a standardised protocol for eliciting and scoring is essential for the study of these reflexes in parkinsonism and other neuropsychiatric conditions.
一项用于检查15种原始反射的标准化方案被应用于25名帕金森病患者和数量相等的健康匹配对照受试者，该方案中分别对反射的幅度和持续时间进行评分。结果发现，大多数反射在患者中出现的频率明显高于对照受试者，尤其是撅嘴反射、眉间轻叩反射及其变体鼻睑反射。只有张口手指伸展反射在对照受试者中出现得更频繁。除了最后这一项反射外，对照组反射的幅度和持续时间得分从未超过患者组。反射在患者中持续的情况比对照受试者更常见。仅帕金森病本身就能解释大量的原始反射，而与疾病的严重程度或病程无关。相比之下，反射的数量与认知量表的关系更为密切。得出的结论是，此类反射可能有助于帕金森病的诊断。此外，对于帕金森病及其他神经精神疾病中这些反射的研究，用于引出和评分的标准化方案至关重要。
