Longo R, Giorgini A, Magnaldi S, Pascazio L, Ricci C
Istituto di Radiologia, Università degli Studi di Trieste, Italy.
Magn Reson Imaging. 1993;11(8):1209-15. doi: 10.1016/0730-725x(93)90249-d.
Two patients affected by severe Alzheimer's disease (AD) were investigated by MRI and image-guided 31P MRS. In one case, 1H MRS was additionally performed. In both cases the diagnosis of AD was confirmed, post mortem, by the pathologist. The spectral parameters of the 31P MR spectra were estimated by fitting the 31P MR signals in the time domain. Our 31P MRS results suggest that it is possible to detect the membrane catabolism, as indexed with the level of PDE resonances visible in in vivo 31P MRS, at least in severe AD cases. The 1H spectrum from AD brain showed a marked decrease of NAA signal respect to choline.
对两名重度阿尔茨海默病（AD）患者进行了MRI和图像引导的31P磁共振波谱（MRS）检查。其中一例还额外进行了1H MRS检查。两例患者死后经病理学家确诊为AD。通过在时域中拟合31P MR信号来估计31P MR谱的光谱参数。我们的31P MRS结果表明，至少在重度AD病例中，可以检测到膜分解代谢，这可通过体内31P MRS中可见的磷酸二酯酶（PDE）共振水平来表征。来自AD脑的1H谱显示，与胆碱相比，N-乙酰天门冬氨酸（NAA）信号显著降低。
