Bogdanović Z, Culo F, Marusić M
Department of Physiology, Zagreb University, School of Medicine, Croatia.
Neoplasma. 1993;40(4):229-33.
The modulation of chemical carcinogenesis by three biological response modifiers was assessed in a mouse model. CBA mice given 20-methylcholanthrene s.c. were treated with peptidoglycan monomer, azure B and indomethacin for one month, either from day 0 or 75 after methylcholanthrene injection to assess their effects on tumor incidence (on days 150 and 300), time of tumor appearance, time of death, and duration and dynamics of tumor growth. All three agents significantly influenced some of the parameters of tumor growth, except tumor incidence on day 300. Highly significant sex differences in tumor appearance and growth were observed. Tumors with late appearance grew faster in comparison to tumors with early appearance. The data presented indicate that the effectiveness of anti-cancer body defense mechanisms can be best defined by the time of tumor appearance.
在一个小鼠模型中评估了三种生物反应调节剂对化学致癌作用的调节。皮下注射20-甲基胆蒽的CBA小鼠，从甲基胆蒽注射后第0天或第75天开始，用肽聚糖单体、天青B和吲哚美辛治疗一个月，以评估它们对肿瘤发生率（在第150天和第300天）、肿瘤出现时间、死亡时间以及肿瘤生长持续时间和动态的影响。除了第300天的肿瘤发生率外，所有三种药物均显著影响了肿瘤生长的一些参数。在肿瘤出现和生长方面观察到了高度显著的性别差异。与早期出现的肿瘤相比，晚期出现的肿瘤生长更快。所呈现的数据表明，抗癌机体防御机制的有效性可以通过肿瘤出现时间来最好地定义。
