Somogyi L, Jukić T, Bukovec Z, Culo F, Marusić M
Department of Physiology, School of Medicine, University of Zagreb, Sestre Milosrdnice University Hospital, Croatia.
Neoplasma. 1994;41(1):17-9.
Sham-gonadectomized and gonadectomized male and female mice were given methylcholanthrene s.c. to assess the influence of sex hormones on carcinogenesis. Gonadectomy decreased the concentration of the respective sex hormone and increased the concentration of the opposite sex hormone. The results showed that androgens enhanced the effectiveness of carcinogenesis, while estrogens had the opposite effect. Gonadectomy effectively abrogated the sex differences in tumor induction.
对假去势和去势的雄性及雌性小鼠进行皮下注射甲基胆蒽，以评估性激素对致癌作用的影响。去势降低了相应性激素的浓度，同时提高了异性激素的浓度。结果表明，雄激素增强了致癌作用的有效性，而雌激素则具有相反的作用。去势有效地消除了肿瘤诱导中的性别差异。
