Braz I, Shandilya L N, Ramaswami L S
Andrologia. 1976;8(4):290-6.
A subtoxic dose of alpha-chlorohydrin (3-chloro-1, 2-propanediol, U-5897) was injected subcutaneously 10 mg/kg for 30 days into adult male langur monkeys (Presbytis). The animals did not lose weight; there was a reduction of weight of the testis and accessories. Histologically, spermatogenesis was suppressed but the interstitial cells appeared normal. In the caput epididymides, the diameter of the tubule was reduced by half as compared to the control and the height of cells was also reduced; in the cauda epididymidis, the cilia were either absent or reduced in size. Sialic acid concentration was reduced in the testis and epididymis of the treated animals; fructose in seminal vesicle and citric acid in prostate were also reduced though morphologically the interstitial cells looked normal, they were functionally anti-anabolic. This appears to be a new profile of alpha-chlorohydrin action in a primate.
将亚毒性剂量的α-氯醇（3-氯-1,2-丙二醇，U-5897）以10毫克/千克的剂量皮下注射到成年雄性叶猴（长尾叶猴属）体内，持续30天。这些动物体重未减轻，但睾丸及附属器官重量减轻。组织学检查显示，精子发生受到抑制，但间质细胞看起来正常。在附睾头部，与对照组相比，小管直径减半，细胞高度也降低；在附睾尾部，纤毛缺失或尺寸减小。处理过的动物的睾丸和附睾中唾液酸浓度降低；精囊中的果糖和前列腺中的柠檬酸也减少，尽管间质细胞在形态上看起来正常，但它们在功能上是抗合成代谢的。这似乎是α-氯醇在灵长类动物中的一种新作用模式。
