人类大脑中元素的浓度：多形性胶质母细胞瘤

Concentration of elements in human brain: glioblastoma multiforme.

作者信息

Andrási E, Suhajda M, Sáray I, Bezúr L, Ernyei L, Réffy A

机构信息

Institute of Inorganic and Analytical Chemistry, L. Eötvös University, Budapest, Hungary.

出版信息

Sci Total Environ. 1993 Nov 1;139-140:399-402. doi: 10.1016/0048-9697(93)90036-6.

DOI:10.1016/0048-9697(93)90036-6

PMID:8272844

Abstract

In this paper the results of two coordinated biomedical research projects are presented. The first project involves the determination of the average values of elements in normal human brain (20 individuals, age-group 65-75). 21 brain parts were selected from both hemispheres. Determinations were carried out by ICP-AES and INAA methods. The main (Na, K, Mg, Ca, Fe, P, S) and trace elements (Al, B, Ba, Co, Cr, Mn, Ni, Pb, Sr, Zn) were investigated. Quality control was ensured by using NBS Bovine Liver SRMs. On the basis of our investigations the regional distribution of elements can be given. The second goal was to detect the possible trace element changes in histopathologically selected brain regions from patients with glioblastoma multiforme. The majority of elements displayed no statistically significant differences between the studied groups, except the reduced levels of B and Zn and the increased level of Sr compared to the tissue from control individuals.

摘要

本文展示了两个协同生物医学研究项目的结果。第一个项目涉及测定正常人类大脑（20名个体，年龄在65 - 75岁之间）中元素的平均值。从两个半球选取了21个脑区。采用电感耦合等离子体发射光谱法（ICP - AES）和仪器中子活化分析法（INAA）进行测定。研究了主要元素（钠、钾、镁、钙、铁、磷、硫）和微量元素（铝、硼、钡、钴、铬、锰、镍、铅、锶、锌）。通过使用美国国家标准与技术研究院（NBS）牛肝标准参考物质（SRMs）确保质量控制。基于我们的研究，可以给出元素的区域分布情况。第二个目标是检测多形性胶质母细胞瘤患者经组织病理学选定的脑区中可能存在的微量元素变化。与对照个体的组织相比，除了硼和锌水平降低以及锶水平升高外，大多数元素在研究组之间没有显示出统计学上的显著差异。