锌及锌转运蛋白改变在阿尔茨海默病进展中的潜在作用。
A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.
作者信息
Lovell Mark A
机构信息
Department of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
出版信息
J Alzheimers Dis. 2009;16(3):471-83. doi: 10.3233/JAD-2009-0992.
Abstract
Although multiple studies have suggested a role for alterations of zinc (Zn) and zinc transport (ZnT) proteins in the pathogenesis of Alzheimer's disease, the exact role of this essential trace element in the progression of the disease remains unclear. The following review discusses the normal role of Zn and ZnT proteins in brain and the potential effects of their alteration in the pathogenesis of Alzheimer's disease, particularly in the processing of the amyloid-beta protein precursor and amyloid-beta peptide generation and aggregation.
摘要
尽管多项研究表明锌（Zn）及锌转运（ZnT）蛋白的改变在阿尔茨海默病发病机制中起一定作用，但这种必需微量元素在疾病进展中的具体作用仍不清楚。以下综述讨论了锌和ZnT蛋白在大脑中的正常作用，以及它们的改变在阿尔茨海默病发病机制中的潜在影响，特别是在淀粉样β蛋白前体的加工以及淀粉样β肽的产生和聚集方面。
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