睫状神经营养因子-白血病抑制因子-抑瘤素M-白细胞介素-6β受体成分对Jak-Tyk激酶的关联与激活作用

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

作者信息

Stahl N, Boulton T G, Farruggella T, Ip N Y, Davis S, Witthuhn B A, Quelle F W, Silvennoinen O, Barbieri G, Pellegrini S

机构信息

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.

出版信息

Science. 1994 Jan 7;263(5143):92-5. doi: 10.1126/science.8272873.

DOI:10.1126/science.8272873

PMID:8272873

Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

摘要

最近定义的一类细胞因子，由睫状神经营养因子（CNTF）、白血病抑制因子（LIF）、制瘤素M（OSM）和白细胞介素-6（IL-6）组成，它们利用Jak-Tyk家族的细胞质酪氨酸激酶。该细胞因子家族的β受体成分，即gp130和LIF受体β，与Jak-Tyk激酶组成性结合。这些激酶的激活是受体β成分配体诱导二聚化的结果。与迄今为止研究的其他细胞因子受体不同，CNTF细胞因子家族的受体利用Jak-Tyk家族的所有已知成员，但在不同细胞系中诱导不同的Jak-Tyk磷酸化模式。