Sletnes K E
Hematologisk forskningslaboratorium, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1993 Nov 20;113(28):3457-9.
Thromboembolic disease is a major clinical problem. This article reviews the etiology and pathogenesis of spontaneous venous thromboembolism. There is an association between thromboembolism and hereditary deficiency of antithrombin III, protein C or protein S. In young patients, impaired fibrinolytic activity may represent the most common haemostatic abnormality associated with thrombosis. Dysfibrinogenaemia has been related to thrombotic disease in some patients. Moreover, the presence of phospholipid directed antibodies is associated with thrombosis in patients with connective tissue disorders. Therefore, for young patients with spontaneous thromboembolic disease, a thorough laboratory investigation is recommended.
血栓栓塞性疾病是一个主要的临床问题。本文综述了自发性静脉血栓栓塞的病因和发病机制。血栓栓塞与抗凝血酶III、蛋白C或蛋白S的遗传性缺乏之间存在关联。在年轻患者中，纤溶活性受损可能是与血栓形成相关的最常见的止血异常。在一些患者中，异常纤维蛋白原血症与血栓性疾病有关。此外，磷脂导向抗体的存在与结缔组织疾病患者的血栓形成有关。因此，对于患有自发性血栓栓塞性疾病的年轻患者，建议进行全面的实验室检查。
